A detailed study of developmental immunotoxicity of imidacloprid in Wistar rats.

نویسندگان

  • Lalita Gawade
  • Shruta S Dadarkar
  • Raghib Husain
  • Madhumanjiri Gatne
چکیده

Human exposure to imidacloprid is likely to occur during its use as an acaricide or an ectoparasiticide. Accordingly, the developmental immunotoxic potential of imidacloprid was investigated. Oral exposure was initiated in timed pregnant female Wistar rats on gestation day 6 (GD 6) till GD 21. On GD 20, half of the gravid dams were sacrificed, and in utero fetal development was assessed. In the other half of the dams, administration was continued till weaning on postnatal day 21 (PND 21) and maternal toxicity was investigated. A subgroup of weaned pups was sacrificed to assess immunotoxicity parameters. The other half of the pups were exposed to imidacloprid till PND 42, and immunotoxicity was assessed. The findings revealed post-implantation loss in the highest dose group, indicating the risk of abortion. Soft tissue abnormalities and skeletal alterations were observed in the highest dose group. Humoral immunity was assessed by estimating hemagglutination titer and immunoglobulin production. Cell mediated immunity was assessed by Delayed Type Hypersensitivity, whereas, non-specific immunity was assessed by phagocytic index, and other phenotypic parameters. These data revealed that imidacloprid caused age-dependent adverse effects on the developing immunity which was aggravated when exposure continued throughout development, leading to a compromised immune system.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

P-172: Teratogenic Effects of Imidacloprid and Precocene1 on Reproductive Ability in Female Wistar Rats

Background: Embryonic development is one of the most critical stages in animal life. This step is strongly influenced by environmental and internal factors. The widespread uses of agricultural pesticide and their teratogenic effect on fetuses is one of the biggest health challenges facing the human. We examined the effects of Imidacloprid (IMI) and Precocene1 (PRE1) on reproductive ability in W...

متن کامل

Effect of Propolis on Immunotoxicity Induced by Phenol Subchronic Use in Adult Albino Rats

Phenol is naturally found in some foods and animal wastes. It is also used as a disinfectant, insecticide and in some pharmaceutical products. Immunotoxicity is considered to be one of the harmful health effects of phenol. Propolis is a mixture of beeswax and resins; it has an antimicrobial, anti-inflammatory, antioxidant and immunomodulatory effect. This study investigates effect of propolis o...

متن کامل

The Effect of Chronic Exposure with Imidacloprid Insecticide on Fertility in Mature Male Rats

Background This study was conducted to evaluate the effect of chronic exposure to imidacloprid (IM) insecticide on male testicular tissue, sperm morphology and testosterone levels in the serum of mature male rats. MaterialsAndMethods Animals were divided into and control-sham groups. The test group was subdivided into two groups of rats which were administered doses of 225 and 112 mg/kg IM per ...

متن کامل

P-198: Study Effects of EMF on Pathology of Ovary in Newborn Rats during Developmental Period

Background: The effect of electromagnetic field (EMF) as an environmental factor on different organs including female reproductive system is of critical concern. In view of the fact that embryo fetuses and young, growing animals are more susceptible to any xenobiotic during gestational and lactation stages of gonadal development may it lead to permanent damage to the gonads. The early phases of...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

دوره 51  شماره 

صفحات  -

تاریخ انتشار 2013